CORTISOL RESPONSE TO BUSPIRONE IN EXTENDED ABSTINENT ALCOHOLICS | Zendy

Yuri Kim | Zendy

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CORTISOL RESPONSE TO BUSPIRONE IN EXTENDED ABSTINENT ALCOHOLICS

Author(s) -

Yuri Kim

Publication year - 2004

Publication title -

alcohol and alcoholism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.747

H-Index - 99

eISSN - 1464-3502

pISSN - 0735-0414

DOI - 10.1093/alcalc/agh068

Subject(s) - buspirone , medicine , psychology , 5 ht1a receptor , hydrocortisone , endocrinology , receptor , 5 ht receptor , agonist , serotonin

We evaluated cortisol response to buspirone in extended abstinent alcoholic patients to determine 5-HT1A receptor sensitivity in alcoholism. Alcoholic patients were inpatients with an extended abstinent period of at least 3 months. Alcoholics had a significantly lower cortisol level than did the normal controls from 60 min through to 150 min after administration of 30 mg buspirone. Our results show that cortisol response to buspirone was significantly decreased in alcoholic patients compared to normal controls, reflecting decreased 5-HT1A receptor sensitivity.

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