Open AccessMICROBES AND MUCOSA IN THE REGULATION OF INTRACOLONIC ACETALDEHYDE CONCENTRATION DURING ETHANOL CHALLENGE
Author(s) -
Jukka-Pekka Visapää
Publication year - 2002
Publication title -
alcohol and alcoholism
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.747
H-Index - 99
eISSN - 1464-3502
pISSN - 0735-0414
DOI - 10.1093/alcalc/37.4.322
Subject(s) - acetaldehyde , disulfiram , aldehyde dehydrogenase , ethanol , chemistry , metronidazole , pharmacology , alcohol dehydrogenase , alcohol , biochemistry , medicine , endocrinology , biology , antibiotics , enzyme
The bacteriocolonic pathway for ethanol oxidation leads to high intracolonic levels of carcinogenic acetaldehyde. The respective roles of colonic mucosal cells and gut flora in the regulation of intracolonic acetaldehyde concentration are not known. Disulfiram inhibits hepatic acetaldehyde oxidation and may have an effect on colonic mucosal cells. On the other hand, metronidazole treatment leads to overgrowth of acetaldehyde-producing aerobic flora in the large intestine. The aim of this study was to characterize by means of disulfiram and metronidazole the contribution of colonic mucosal cells and intracolonic microbes to the regulation of intracolonic acetaldehyde concentration during ethanol oxidation in rats.
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