Open AccessXanthine Oxidase Inhibitor, Febuxostat Ameliorates the High Salt Intake–Induced Cardiac Hypertrophy and Fibrosis in Dahl Salt-Sensitive Rats
Author(s) -
Asako Namai-Takahashi,
Akihiro Sakuyama,
Takahiro Nakamura,
Takahiro Miura,
Junta Takahashi,
Ryo Kurosawa,
Masahiro Kohzuki,
Osamu Ito
Publication year - 2018
Publication title -
american journal of hypertension
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.009
H-Index - 136
eISSN - 1941-7225
pISSN - 0895-7061
DOI - 10.1093/ajh/hpy143
Subject(s) - medicine , endocrinology , febuxostat , nadph oxidase , angiotensin ii , xanthine oxidase , xanthine oxidase inhibitor , nicotinamide adenine dinucleotide phosphate , muscle hypertrophy , oxidase test , cardiac fibrosis , uric acid , fibrosis , blood pressure , hyperuricemia , chemistry , oxidative stress , biochemistry , enzyme
Xanthine oxidase (XO) is a source of reactive oxygen species production in the heart. However, pathophysiological role of XO has not been clarified in hypertensive heart disease. Thus, the present study examined the impacts of high salt (HS) intake and febuxostat (Fx), a XO inhibitor in Dahl salt-sensitive (Dahl-S) rats.
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