Age-Related Expression of Human AT1R Variants and Associated Renal Dysfunction in Transgenic Mice | Zendy

Sudhir Jain | Zendy; Anita Rana | Zendy; Kavita Jain | Zendy; Sravan Perla | Zendy; Nitin Puri | Zendy; Ashok Kumar | Zendy

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Age-Related Expression of Human AT1R Variants and Associated Renal Dysfunction in Transgenic Mice

Author(s) -

Sudhir Jain,

Anita Rana,

Kavita Jain,

Sravan Perla,

Nitin Puri,

Ashok Kumar

Publication year - 2018

Publication title -

american journal of hypertension

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.009

H-Index - 136

eISSN - 1941-7225

pISSN - 0895-7061

DOI - 10.1093/ajh/hpy121

Subject(s) - gene expression , endocrinology , angiotensin ii , genetically modified mouse , haplotype , medicine , gene , transgene , transcriptional regulation , microbiology and biotechnology , biology , receptor , allele , genetics

The contribution of single nucleotide polymorphisms in transcriptional regulation of the human angiotensin receptor type I (hAT1R) gene in age-related chronic pathologies such as hypertension and associated renal disorders is not well known. The hAT1R gene has single nucleotide polymorphisms in its promoter that forms 2 haplotypes (Hap), Hap-I and Hap-II. Hap-I of AT1R gene is associated with hypertension in Caucasians. We have hypothesized here that age will alter the transcriptional environment of the cell and will regulate the expression of hAT1R gene in a haplotype-dependent manner. This could likely make subjects with Hap-I increasingly susceptible to age-associated, AT1R-mediated complications.

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