Renal Protective Effects of N-Acetyl-Seryl-Aspartyl-Lysyl-Proline (Ac-SDKP) in Obese Rats on a High-Salt Diet | Zendy

Mani Maheshwari | Zendy; César A. Romero | Zendy; Sumit R. Monu | Zendy; Nitin Kumar | Zendy; TangDong Liao | Zendy; Edward L. Peterson | Zendy; Oscar A. Carretero | Zendy

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Renal Protective Effects of N-Acetyl-Seryl-Aspartyl-Lysyl-Proline (Ac-SDKP) in Obese Rats on a High-Salt Diet

Author(s) -

Mani Maheshwari,

César A. Romero,

Sumit R. Monu,

Nitin Kumar,

TangDong Liao,

Edward L. Peterson,

Oscar A. Carretero

Publication year - 2018

Publication title -

american journal of hypertension

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.009

H-Index - 136

eISSN - 1941-7225

pISSN - 0895-7061

DOI - 10.1093/ajh/hpy052

Subject(s) - medicine , endocrinology , inflammation , fibrosis , kidney , glomerulosclerosis , albuminuria , blood pressure , proteinuria

Obesity is a public health problem, associated with salt sensitive hypertension, kidney inflammation, and fibrosis. N-acetyl-seryl-aspartyl-lysyl-proline (Ac-SDKP) is a tetra peptide with anti-inflammatory and anti-fibrotic properties. However, its effect on preventing kidney damage in obesity is unknown. We hypothesized that Zucker obese (ZO) rats on a high-salt (HS) diet develop renal damage, inflammation, fibrosis, and this is prevented with Ac-SDKP treatment.

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