Open AccessPolymorphisms Within RYR3 Gene Are Associated With Risk and Age at Onset of Hypertension, Diabetes, and Alzheimer’s Disease
Author(s) -
Shaoqing Gong,
Bin Su,
Hugo Tovar,
ChunXiang Mao,
Valeria González,
Ying Liu,
Yongke Lu,
Kesheng Wang,
Chun Xu
Publication year - 2018
Publication title -
american journal of hypertension
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.009
H-Index - 136
eISSN - 1941-7225
pISSN - 0895-7061
DOI - 10.1093/ajh/hpy046
Subject(s) - medicine , diabetes mellitus , single nucleotide polymorphism , ryanodine receptor , disease , endocrinology , bioinformatics , gene , genetics , genotype , calcium , biology
Hypertension affects 33% of Americans while type 2 diabetes and Alzheimer's disease (AD) affect 10% of Americans, respectively. Ryanodine receptor 3 gene (RYR3) codes for the RYR which functions to release stored endoplasmic reticulum calcium ions (Ca2+) to increase intracellular Ca2+ concentration. Increasing studies demonstrate that altered levels of intracellular Ca2+ affect cardiac contraction, insulin secretion, and neurodegeneration. In this study, we investigated associations of the RYR3 genetic variants with hypertension, AD, and diabetes.
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