Open AccessAT1 Receptor Antagonism Improves Structural, Functional, and Biomechanical Properties in Resistance Arteries in a Rodent Chronic Kidney Disease Model
Author(s) -
Ko Jin Quek,
Omar Z. Ameer,
Jacqueline K. Phillips
Publication year - 2018
Publication title -
american journal of hypertension
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.009
H-Index - 136
eISSN - 1941-7225
pISSN - 0895-7061
DOI - 10.1093/ajh/hpy021
Subject(s) - medicine , endocrinology , valsartan , angiotensin ii , creatinine , kidney disease , angiotensin ii receptor type 1 , blood pressure
The renin-angiotensin system, in particular Angiotensin II (AngII), plays a significant role in the pathogenesis of hypertension in chronic kidney disease (CKD). Effects of chronic AT1 receptor antagonism were investigated in a genetic hypertensive rat model of CKD, the Lewis polycystic kidney (LPK) rat.
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