Carotid Body Denervation Markedly Improves Survival in Rats With Hypertensive Heart Failure | Zendy

Kana Fujii | Zendy; Keita Saku | Zendy; Takuya Kishi | Zendy; Yasuhiro Oga | Zendy; Takeshi Tohyama | Zendy; Takuya Nishikawa | Zendy; Takafumi Sakamoto | Zendy; Masataka Ikeda | Zendy; Tomomi Ide | Zendy; Hiroyuki Tsutsui | Zendy; Kenji Sunagawa | Zendy

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Carotid Body Denervation Markedly Improves Survival in Rats With Hypertensive Heart Failure

Author(s) -

Kana Fujii,

Keita Saku,

Takuya Kishi,

Yasuhiro Oga,

Takeshi Tohyama,

Takuya Nishikawa,

Takafumi Sakamoto,

Masataka Ikeda,

Tomomi Ide,

Hiroyuki Tsutsui,

Kenji Sunagawa

Publication year - 2017

Publication title -

american journal of hypertension

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.009

H-Index - 136

eISSN - 1941-7225

pISSN - 0895-7061

DOI - 10.1093/ajh/hpx062

Subject(s) - medicine , heart failure , natriuresis , blood pressure , cardiology , left ventricular hypertrophy , hemodynamics , denervation , muscle hypertrophy , endocrinology

Hypertension is a major cause of heart failure. Excessive sympathoexcitation in patients with heart failure leads to poor prognosis. Since carotid body denervation (CBD) has been shown to reduce sympathetic nerve activity in animal models of hypertension and heart failure, we examined if bilateral CBD attenuates the progression of hypertensive heart failure and improves survival.

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