Open AccessAssociation of Mineralocorticoid Receptor Polymorphism I180V With Left Ventricular Hypertrophy in Resistant Hypertension
Author(s) -
Alessandra Mileni Versuti Ritter,
Vanessa Fontana,
Ana Paula de Faria,
Rodrigo Modolo,
Natália R. Barbaro,
A. Sabbatini,
Heverton Alves Peres,
Celso Biagi,
Pamela S. Silva,
Paulo César Lopes,
José E. TanusSantos,
Eduardo Barbosa Coelho,
Heitor Moreno
Publication year - 2015
Publication title -
american journal of hypertension
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.009
H-Index - 136
eISSN - 1941-7225
pISSN - 0895-7061
DOI - 10.1093/ajh/hpv070
Subject(s) - mineralocorticoid receptor , aldosterone synthase , medicine , microalbuminuria , left ventricular hypertrophy , endocrinology , aldosterone , genotype , haplotype , blood pressure , allele , pulse wave velocity , mineralocorticoid , muscle hypertrophy , ambulatory blood pressure , cardiology , biology , renin–angiotensin system , genetics , gene
Genetic polymorphisms on mineralocorticoid receptor gene (NC3C2) are associated with variability of mineralocorticoid receptor (MR) function and cardiovascular implications. We sought to investigate whether I180V (rs5522) and MRc.-2G_C (rs2070951) polymorphisms in NR3C2 gene are associated with resistance to antihypertensive treatment and target-organ damage in resistant hypertensive (RHTN) patients.
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