Expression of Calcium Channel Subunit Variants in Small Mesenteric Arteries of WKY and SHR | Zendy

R. H. Cox | Zendy; Samantha Fromme | Zendy

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Expression of Calcium Channel Subunit Variants in Small Mesenteric Arteries of WKY and SHR

Author(s) -

R. H. Cox,

Samantha Fromme

Publication year - 2015

Publication title -

american journal of hypertension

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.009

H-Index - 136

eISSN - 1941-7225

pISSN - 0895-7061

DOI - 10.1093/ajh/hpv024

Subject(s) - medicine , endocrinology , cav1.2 , messenger rna , mesenteric arteries , myocyte , microbiology and biotechnology , calcium channel , calcium , artery , biology , gene , genetics

Enhanced function of dihydropyridine-sensitive Ca2+ channels (CaV) in hypertensive arterial myocytes (HAM) is well accepted. Increased protein expression of pore forming α1-subunits contributes to this effect, but cannot explain all of the differences in CaV properties in HAM. We hypothesized that differences in expression of CaV subunits and/or their splice variants also contribute.

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