Open AccessElevation of (Pro)Renin and (Pro)Renin Receptor in Preeclampsia
Author(s) -
Jessica L. Thomason,
Michelle Reyes,
Steven R. Allen,
Richard O. Jones,
Madhava Beeram,
Thomas J. Kuehl,
Fumiaki Suzuki,
Mohammad N Uddin
Publication year - 2015
Publication title -
american journal of hypertension
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.009
H-Index - 136
eISSN - 1941-7225
pISSN - 0895-7061
DOI - 10.1093/ajh/hpv019
Subject(s) - renin–angiotensin system , preeclampsia , medicine , receptor , endocrinology , proteinuria , kidney , plasma renin activity , biology , pregnancy , blood pressure , genetics
Preeclampsia (preE), a syndrome of hypertension, proteinuria, and edema, has many elusive triggers. The renin-angiotensin system has been implicated in preE pathogenesis. In this study, we test the hypothesis that (pro)renin levels are increased in preE patients and that levels of (pro)renin and (pro)renin receptor ((P)RR) are elevated in a rat model of preE.
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