A Combination of Intravenous Genistein Plus Mg2+Enhances Antihypertensive Effects in SHR by Endothelial Protection and BKCaChannel Inhibition | Zendy

Lina Sun | Zendy; Tingting Zhao | Zendy; Ting Ju | Zendy; Xiaoran Wang | Zendy; Xiaoli Li | Zendy; Lei Wang | Zendy; Liming Zhang | Zendy; Guichun Yu | Zendy

Open Access

A Combination of Intravenous Genistein Plus Mg²⁺Enhances Antihypertensive Effects in SHR by Endothelial Protection and BK_CaChannel Inhibition

Author(s) -

Lina Sun,

Tingting Zhao,

Ting Ju,

Xiaoran Wang,

Xiaoli Li,

Lei Wang,

Liming Zhang,

Guichun Yu

Publication year - 2015

Publication title -

american journal of hypertension

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.009

H-Index - 136

eISSN - 1941-7225

pISSN - 0895-7061

DOI - 10.1093/ajh/hpv005

Subject(s) - medicine , blood pressure , endocrinology , nifedipine , endothelial dysfunction , mesenteric arteries , plethysmograph , spontaneously hypertensive rat , genistein , calcium , artery

The effects of combining genistein (GST) plus magnesium (Mg) upon the development of hypertension were examined in 28 twelve-week-old male spontaneous hypertension rats (SHRs). Four experimental groups were tested: SHR (0.9% NaCl and DMSO), SHR + GST (0.9% NaCl and GST 5mg/kg/day), SHR + Mg (Mg(2+) 0.75 mmol/kg/day and DMSO), and SHR + GST + Mg (Mg(2+) 0.75 mmol/kg/day and GST 5mg/kg/day). A group of normotensive genetic control, Wistar-Kyoto (WKY) rats were also included for comparison. Drugs were administrated intravenously daily for 30 days.

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