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The effects of combining genistein (GST) plus magnesium (Mg) upon the development of hypertension were examined in 28 twelve-week-old male spontaneous hypertension rats (SHRs). Four experimental groups were tested: SHR (0.9% NaCl and DMSO), SHR + GST (0.9% NaCl and GST 5mg/kg/day), SHR + Mg (Mg(2+) 0.75 mmol/kg/day and DMSO), and SHR + GST + Mg (Mg(2+) 0.75 mmol/kg/day and GST 5mg/kg/day). A group of normotensive genetic control, Wistar-Kyoto (WKY) rats were also included for comparison. Drugs were administrated intravenously daily for 30 days.

american journal of hypertension

A Combination of Intravenous Genistein Plus Mg<sup>2+</sup>Enhances Antihypertensive Effects in SHR by Endothelial Protection and BK<sub>Ca</sub>Channel Inhibition

A Combination of Intravenous Genistein Plus Mg2+Enhances Antihypertensive Effects in SHR by Endothelial Protection and BKCaChannel Inhibition

A Combination of Intravenous Genistein Plus Mg²⁺Enhances Antihypertensive Effects in SHR by Endothelial Protection and BK_CaChannel Inhibition