Open AccessActivation of Central Angiotensin Type 2 Receptors by Compound 21 Improves Arterial Baroreflex Sensitivity in Rats With Heart Failure
Author(s) -
Juan Gao,
Irving H. Zucker,
Li Gao
Publication year - 2014
Publication title -
american journal of hypertension
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.009
H-Index - 136
eISSN - 1941-7225
pISSN - 0895-7061
DOI - 10.1093/ajh/hpu044
Subject(s) - baroreflex , medicine , endocrinology , rostral ventrolateral medulla , angiotensin ii , mean arterial pressure , blood pressure , renin–angiotensin system , heart rate
In a previous study we demonstrated that central administration of compound 21 (C21), a nonpeptide AT2R agonist, inhibited sympathetic tone in normal rats. In this study, we hypothesized that C21 exerts a similar effect in rats with coronary ligation-induced heart failure (HF).
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