Open AccessRenin-Angiotensin System Genetic Polymorphisms and Brain White Matter Lesions in Older Australians
Author(s) -
Amelia A. Assareh,
Karen A. Mather,
John D. Crawford,
Wei Wen,
Kaarin J. Anstey,
Simon Easteal,
Xiaoyan Tan,
Holly A. Mack,
John B. Kwok,
Peter R. Schofield,
Perminder S. Sachdev
Publication year - 2014
Publication title -
american journal of hypertension
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.009
H-Index - 136
eISSN - 1941-7225
pISSN - 0895-7061
DOI - 10.1093/ajh/hpu035
Subject(s) - medicine , renin–angiotensin system , white matter , angiotensin ii , magnetic resonance imaging , cardiology , blood pressure , radiology
White matter lesions (WMLs), seen as hyperintensities on T2-weighted magnetic resonance imaging brain scans, are common in the brains of healthy older individuals. They are thought to be related to cerebral small vessel disease and to have a genetic component to their aetiology, and hypertension is thought to be an important risk factor. Genetic polymorphisms in hypertension-related genes may therefore be associated with the formation of WMLs.
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