Open AccessRetinoid X Receptor Agonists Inhibit Hypertension-Induced Myocardial Hypertrophy by Modulating LKB1/AMPK/p70S6K Signaling Pathway
Author(s) -
Jiang Zhu,
Ruobing Ning,
Xiaoyan Lin,
Dajun Chai,
Changsheng Xu,
Hong Xie,
Jin-Zhang Zeng,
Jinxiu Lin
Publication year - 2014
Publication title -
american journal of hypertension
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 1.009
H-Index - 136
eISSN - 1941-7225
pISSN - 0895-7061
DOI - 10.1093/ajh/hpu017
Subject(s) - endocrinology , medicine , bexarotene , ampk , angiotensin ii , retinoid x receptor , agonist , muscle hypertrophy , receptor , biology , protein kinase a , kinase , microbiology and biotechnology , biochemistry , nuclear receptor , transcription factor , gene
Retinoid X receptor (RXR) has been demonstrated to play an important role in cardiac development and has been implicated in cardiovascular diseases. This study aimed to examine the effects of RXRα agonist bexarotene on pathological left ventricular hypertrophy (LVH) in a spontaneously hypertensive rat (SHR) model and the underlying mechanism.
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