Renin-Angiotensin System Blockers May Create More Risk Than Reward for Sodium-Depleted Cardiovascular Patients With High Plasma Renin Levels | Zendy

J E Sealey | Zendy; Michael H. Alderman | Zendy; Curt D. Furberg | Zendy; J. H. Laragh | Zendy

Open Access

Renin-Angiotensin System Blockers May Create More Risk Than Reward for Sodium-Depleted Cardiovascular Patients With High Plasma Renin Levels

Author(s) -

J E Sealey,

Michael H. Alderman,

Curt D. Furberg,

J. H. Laragh

Publication year - 2013

Publication title -

american journal of hypertension

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.009

H-Index - 136

eISSN - 1941-7225

pISSN - 0895-7061

DOI - 10.1093/ajh/hpt034

Subject(s) - medicine , plasma renin activity , renin–angiotensin system , blood pressure , endocrinology , angiotensin ii , low sodium , cardiology , sodium , chemistry , organic chemistry

Four recent reports revealed differences in survival rates among treated cardiovascular patients taking renin-angiotensin system-blocking drugs. Patients with higher on-treatment plasma renin activity (PRA) levels died sooner of cardiovascular mortality than those with lower levels. We investigated whether excessive sodium depletion might have induced the higher PRA levels and contributed to the greater morbidity and mortality.

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