A Possible Interaction Between Systemic and Renal Angiotensinogen in the Control of Blood Pressure | Zendy

Nirupama Ramkumar | Zendy; Deborah Stuart | Zendy; Jianming Ying | Zendy; Donald E. Kohan | Zendy

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A Possible Interaction Between Systemic and Renal Angiotensinogen in the Control of Blood Pressure

Author(s) -

Nirupama Ramkumar,

Deborah Stuart,

Jianming Ying,

Donald E. Kohan

Publication year - 2013

Publication title -

american journal of hypertension

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.009

H-Index - 136

eISSN - 1941-7225

pISSN - 0895-7061

DOI - 10.1093/ajh/hps078

Subject(s) - medicine , endocrinology , renin–angiotensin system , kidney , sodium , angiotensin ii , blood pressure , plasma renin activity , excretion , distal convoluted tubule , chemistry , reabsorption , organic chemistry

Angiotensinogen (AGT) is synthesized in the liver and proximal tubule. AGT overexpression at either site might increase blood pressure (BP). We used transgenic mice with AGT overexpression in proximal tubule (K), liver (L), or both sites (KL) to determine the relative contributions of hepatic- and proximal tubule-derived AGT in modulating BP.

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