N-Terminal Rather Than Full-Length Osteopontin or Its C-Terminal Fragment Is Associated With Carotid-Plaque Inflammation in Hypertensive Patients | Zendy

Talya Wolak | Zendy; Νeta Sion-Vardi | Zendy; Victor Novack | Zendy; George Greenberg | Zendy; Gabriel Szendro | Zendy; Tanya Tarnovscki | Zendy; Ori Nov | Zendy; Ilan Shelef | Zendy; Esther Paran | Zendy; Assaf Rudich | Zendy

Open Access

N-Terminal Rather Than Full-Length Osteopontin or Its C-Terminal Fragment Is Associated With Carotid-Plaque Inflammation in Hypertensive Patients

Author(s) -

Talya Wolak,

Νeta Sion-Vardi,

Victor Novack,

George Greenberg,

Gabriel Szendro,

Tanya Tarnovscki,

Ori Nov,

Ilan Shelef,

Esther Paran,

Assaf Rudich

Publication year - 2013

Publication title -

american journal of hypertension

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.009

H-Index - 136

eISSN - 1941-7225

pISSN - 0895-7061

DOI - 10.1093/ajh/hps043

Subject(s) - osteopontin , inflammation , medicine , cd68 , pathology , carotid endarterectomy , immunohistochemistry , matrix metalloproteinase , western blot , stenosis , biology , biochemistry , gene

Hypertensive patients develop carotid atherosclerotic plaques with enhanced inflammation. Full-length osteopontin (OPN-FL), a multifunctional protein whose levels are elevated in association with atherosclerosis, is cleaved by thrombin and matrix metalloproteinases to form a C-terminal and a putatively biologically active N-terminal fragment (OPN-C, OPN-N, respectively). We conducted a study to examine whether plaque inflammation in hypertensive patients corresponds to the expression of OPN or of its cleaved forms or both.

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