Relationship Between the Accumulation of Metabolic Syndrome Components and Orthostatic Hypotension

Background To investigate the relationship between the accumulation of metabolic syndrome (MS) components and orthostatic hypotension (OH). Methods A total of 2,201 subjects were enrolled and divided into 0 component (n = 199), 1–2 components (n = 1,003), and 3–4 components (n = 999) groups based on the number of MS components according to the criteria of 2018 Chinese Guidelines for Prevention and Management of Hypertension. Stratified analyses and binary logistic regression analysis were performed. Results The incidence of OH was significantly increased with the number of MS components (5.0% in 0 component group, 13.5% in 1–2 components group, and 17.9% in 3–4 components group, P < 0.05). Compared with subjects without OH, the incidence of MS in those with OH was significantly elevated (55.2% vs. 43.7%, P < 0.05). The incidence of OH in the elderly subjects was significantly higher than that in the young and middle-aged subjects (22.3% vs. 10.9%, P < 0.01). Binary logistic regression analysis showed that the number of MS components was associated with OH in all subjects, and the risk of OH was increased with the increment of MS components. Compared with the subjects without any MS component, the risk of OH increased by 2.3 times in the subjects with 4 MS components (odds ratio = 3.274, 95% confidence interval 1.626–6.594, P < 0.05). Stratified analyses found that the number of MS components was independently associated with OH in young to middle-age, female and non-MS subjects. Conclusions The incidence of OH is elevated with accumulations of MS components, especially in young to middle-age, female and non-MS subjects.