Endothelin Does Not Affect Intracellular Calcium Ion Concentration in the Platelets of Rats | Zendy

Kouichi Murakawa | Zendy; Masakazu Kohno | Zendy; Koji Yokokawa | Zendy; K. Yasunari | Zendy; Naotsugu Kurihara | Zendy; Atsushi Hyono | Zendy; T. Takeda | Zendy

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Endothelin Does Not Affect Intracellular Calcium Ion Concentration in the Platelets of Rats

Author(s) -

Kouichi Murakawa,

Masakazu Kohno,

Koji Yokokawa,

K. Yasunari,

Naotsugu Kurihara,

Atsushi Hyono,

T. Takeda

Publication year - 1990

Publication title -

american journal of hypertension

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.009

H-Index - 136

eISSN - 1941-7225

pISSN - 0895-7061

DOI - 10.1093/ajh/3.4.307

Subject(s) - aequorin , platelet , endothelin receptor , calcium , fura 2 , medicine , endocrinology , intracellular , photoprotein , calcium in biology , endothelin 1 , biophysics , biochemistry , chemistry , biology , cytosol , receptor , enzyme

We recently demonstrated that porcine endothelin increases intracellular calcium ion concentration ([Ca2+]i) in monolayers of cultured vascular smooth muscle cells isolated from rat renal arteries. The present study was designed to examine the effect of porcine endothelin on [Ca2+]i in the platelets of rats. [Ca2+]i was serially measured with the fluorescent dye, fura 2, and the photoprotein, aequorin. Endothelin (10(-9) mol/L, 10(-8) mol/L, and 10(-7) mol/L) did not induce any change in [Ca2+]i in the platelets of rats while thrombin (2 U/mL) dramatically increased [Ca2+]i as measured by these methods. Our results indicate that [Ca2+]i in rat platelets is not influenced by porcine endothelin.

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