A Novel Cell Type in the Parathyroid Glands of Spontaneously Hypertensive Rats | Zendy

Toyoji Kaneko | Zendy; Ritsuko Ohtani | Zendy; Richard Lewanczuk | Zendy; Peter K.T. Pang | Zendy

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A Novel Cell Type in the Parathyroid Glands of Spontaneously Hypertensive Rats

Author(s) -

Toyoji Kaneko,

Ritsuko Ohtani,

Richard Lewanczuk,

Peter K.T. Pang

Publication year - 1989

Publication title -

american journal of hypertension

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.009

H-Index - 136

eISSN - 1941-7225

pISSN - 0895-7061

DOI - 10.1093/ajh/2.7.549

Subject(s) - medicine , parathyroid hormone , endocrinology , parathyroid gland , spontaneously hypertensive rat , parathyroid chief cell , calcium , blood pressure

Recently, we described a circulating hypertensive factor, present in the plasma of spontaneously hypertensive rats (SHR). This factor seems to be produced by the parathyroid gland but is not identical to parathyroid hormone (PTH). In view of these findings, we attempted to search for histological differences in parathyroid glands between SHR and normotensive Wistar-Kyoto (WKY) rats by light and electron microscopy. Novel cells, distinct from normal chief cells, were frequently found in parathyroid glands of SHR rats, whereas they were scarcely observed in WKY rats. Our findings suggest that the novel cells are involved in the development of hypertension in SHR rats.

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