Effect of Chloride on Blood Pressure and Sympathetic Nervous System Activity in Deoxycorticosterone Acetate-Treated Rats | Zendy

Tetsuo Miki | Zendy; Hiroshi Sano | Zendy; Hiroshi Suzuki | Zendy; Jun Kawahara | Zendy; Kaoru Hattori | Zendy; Komei Saito | Zendy; Yutaka Furuta | Zendy; HISASHI FUKUZAKI | Zendy

Open Access

Effect of Chloride on Blood Pressure and Sympathetic Nervous System Activity in Deoxycorticosterone Acetate-Treated Rats

Author(s) -

Tetsuo Miki,

Hiroshi Sano,

Hiroshi Suzuki,

Jun Kawahara,

Kaoru Hattori,

Komei Saito,

Yutaka Furuta,

HISASHI FUKUZAKI

Publication year - 1989

Publication title -

american journal of hypertension

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.009

H-Index - 136

eISSN - 1941-7225

pISSN - 0895-7061

DOI - 10.1093/ajh/2.4.253

Subject(s) - sympathetic nervous system , blood pressure , norepinephrine , sodium , medicine , endocrinology , chloride , autonomic nervous system , heart rate , chemistry , dopamine , organic chemistry

The effect of selective chloride loading on blood pressure and sympathetic nervous system activity was studied in deoxycorticosterone acetate (DOCA)-treated rats. The rats fed a normal sodium-high chloride and fed a high sodium chloride diet had higher blood pressure and lower cardiac norepinephrine concentrations than those fed a normal sodium chloride diet. Furthermore, cardiac norepinephrine concentrations were significantly correlated with systolic blood pressure. These data suggest that selective chloride loading can raise blood pressure in DOCA-treated rats due to augmented sympathetic nervous system activity.

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