Differences of Ca2+ Regulation Between Fibroblasts From Blacks and Whites | Zendy

Akitoshi Nakamura | Zendy; Norio Hatori | Zendy; Makiko Nakamura | Zendy; Burton P. Fine | Zendy; Abraham Aviv | Zendy

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Differences of Ca2+ Regulation Between Fibroblasts From Blacks and Whites

Author(s) -

Akitoshi Nakamura,

Norio Hatori,

Makiko Nakamura,

Burton P. Fine,

Abraham Aviv

Publication year - 1989

Publication title -

american journal of hypertension

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.009

H-Index - 136

eISSN - 1941-7225

pISSN - 0895-7061

DOI - 10.1093/ajh/2.2.105

Subject(s) - washout , medicine , fibroblast , cytosol , endocrinology , basal (medicine) , in vitro , genetics , biology , diabetes mellitus , biochemistry , enzyme

To explore the underlying causes predisposing blacks to essential hypertension, we have studied 45Ca2+ washout and cytosolic free Ca2+ (Cai2+) in quiescent skin fibroblasts from normotensive blacks and whites. Under basal conditions, there were no racial differences in 45Ca2+ washout and Cai2+. However, when stimulated by human serum, fibroblasts from blacks exhibited a higher 45Ca2+ washout associated with higher levels of Cai2+ transients than fibroblasts from whites. We conclude that fibroblasts from blacks demonstrate increased responsiveness to agonists in serum. If the same trend exists in vascular smooth muscle cells, it may predispose blacks to essential hypertension.

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