Comparisons of the Strength of Associations With Future Type 2 Diabetes Risk Among Anthropometric Obesity Indicators, Including Waist-to-Height Ratio: A Meta-Analysis | Zendy

Satoru Kodama | Zendy; Chika Horikawa | Zendy; Kazuya Fujihara | Zendy; Yoriko Heianza | Zendy; Reiko Hirasawa | Zendy; Yoko Yachi | Zendy; Ayumi Sugawara | Zendy; Shiro Tanaka | Zendy; Hitoshi Shimano | Zendy; Keiichi Iida | Zendy; Kohei Saito | Zendy; Hirohito Sone | Zendy

Open Access

Comparisons of the Strength of Associations With Future Type 2 Diabetes Risk Among Anthropometric Obesity Indicators, Including Waist-to-Height Ratio: A Meta-Analysis

Author(s) -

Satoru Kodama,

Chika Horikawa,

Kazuya Fujihara,

Yoriko Heianza,

Reiko Hirasawa,

Yoko Yachi,

Ayumi Sugawara,

Shiro Tanaka,

Hitoshi Shimano,

Keiichi Iida,

Kohei Saito,

Hirohito Sone

Publication year - 2012

Publication title -

american journal of epidemiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.33

H-Index - 256

eISSN - 1476-6256

pISSN - 0002-9262

DOI - 10.1093/aje/kws172

Subject(s) - waist to height ratio , medicine , relative risk , body mass index , meta analysis , waist , waist–hip ratio , type 2 diabetes , obesity , diabetes mellitus , demography , confidence interval , endocrinology , sociology

The aim of this meta-analysis was to compare the association of waist-to-height ratio (WHtR) with risk of incident diabetes with the associations of 3 other conventional obesity indicators (body mass index (BMI), waist circumference (WC), and waist-to-hip ratio (WHR)) with risk of incident diabetes. Literature searches in MEDLINE (January 1950 to April 27, 2011) and EMBASE (January 1974 to April 27, 2011) were conducted for prospective studies that made it possible to estimate the relative risk of diabetes per 1-standard deviation increase in WHtR, in addition to the RR of BMI, WC, or WHR. Strength of the estimated pooled relative risk for a 1-standard deviation increase of each indicator (expressed as RR(WHtR), RR(BMI), RR(WC), and RR(WHR)) was compared with a bivariate random-effects model. Pooled relative risks of the 15 eligible studies with 6,472 diabetes cases were 1.62 (95% CI: 1.48, 1.78) for RR(WHtR), 1.55 (95% CI: 1.43, 1.69) for RR(BMI), 1.63 (95% CI: 1.49, 1.79) for RR(WC), and 1.52 (95% CI: 1.40, 1.66) for RR(WHR). WHtR had an association stronger than that of BMI (P<0.001) or WHR (P<0.001). The present meta-analysis showed that WHtR has a modestly but statistically greater importance than BMI and WHR in prediction of diabetes. Nevertheless, measuring height in addition to WC appeared to have no additional benefit.

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