Systematic Review and Meta-Analysis of the Association between β2-Adrenoceptor Polymorphisms and Asthma: A HuGE Review | Zendy

Ammarin Thakkinstian | Zendy; Mark McEvoy | Zendy; Cosetta Minelli | Zendy; Peter G. Gibson | Zendy; Robert J. Hancox | Zendy; David L. Duffy | Zendy; John R. Thompson | Zendy; Ian P. Hall | Zendy; Joel D. Kaufman | Zendy; Ting Fan Leung | Zendy; Peter Joseph Benedict Helms | Zendy; Hákon Hákonarson | Zendy; Eva Halpi | Zendy; Ruth Navon | Zendy; John Attia | Zendy

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Systematic Review and Meta-Analysis of the Association between β2-Adrenoceptor Polymorphisms and Asthma: A HuGE Review

Author(s) -

Ammarin Thakkinstian,

Mark McEvoy,

Cosetta Minelli,

Peter G. Gibson,

Robert J. Hancox,

David L. Duffy,

John R. Thompson,

Ian P. Hall,

Joel D. Kaufman,

Ting Fan Leung,

Peter Joseph Benedict Helms,

Hákon Hákonarson,

Eva Halpi,

Ruth Navon,

John Attia

Publication year - 2005

Publication title -

american journal of epidemiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.33

H-Index - 256

eISSN - 1476-6256

pISSN - 0002-9262

DOI - 10.1093/aje/kwi184

Subject(s) - odds ratio , haplotype , asthma , linkage disequilibrium , confidence interval , genotype , allele , medicine , meta analysis , heterozygote advantage , polymorphism (computer science) , genetics , endocrinology , biology , gene

A number of studies have investigated two common polymorphisms in the beta(2)-adrenoceptor gene, Arg/Gly16 and Gln/Glu27, in relation to asthma susceptibility. The authors performed a meta-analysis of each polymorphism, as well as haplotype analysis, for adult and pediatric populations separately, using published data, supplemented by additional data requested from the original authors. Individual analysis detected no effect of Arg/Gly16 in adults but did suggest a recessive protective effect of Gly16 for children, with an odds ratio of 0.71 (95% confidence interval (CI): 0.53, 0.96) compared with the other genotypes. Results for Gln/Glu27 in adults seem to indicate that heterozygotes are at decreased risk of asthma than either homozygote (odds ratio = 0.73, 95% CI: 0.62, 0.87), although the studies are heterogeneous; in children, the Glu/Glu genotype has a decreased risk of asthma (odds ratio = 0.60, 95% CI: 0.35, 0.99) compared with the other genotypes. Despite the proximity of these two polymorphic sites, the linkage disequilibrium coefficient of 0.41 was not high (p < 0.001). Haplotype analysis suggests that there may be an interaction between the two sites, with a lower risk of asthma associated with the Glu27 allele (compared with Gln27), and that this risk is modified by the allele at position 16.

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