Neurodegenerative Diseases and Exposure to Pesticides in the Elderly | Zendy

Isabelle Baldi | Zendy; Pierre Lebailly | Zendy; Brahim MohammedBrahim | Zendy; Luc Letenneur | Zendy; JeanFrançois Dartigues | Zendy; Patrick Brochard | Zendy

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Neurodegenerative Diseases and Exposure to Pesticides in the Elderly

Author(s) -

Isabelle Baldi,

Pierre Lebailly,

Brahim MohammedBrahim,

Luc Letenneur,

JeanFrançois Dartigues,

Patrick Brochard

Publication year - 2003

Publication title -

american journal of epidemiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.33

H-Index - 256

eISSN - 1476-6256

pISSN - 0002-9262

DOI - 10.1093/aje/kwf216

Subject(s) - confidence interval , medicine , confounding , pesticide , environmental health , occupational exposure , prospective cohort study , cohort study , disease , cohort , toxicology , biology , agronomy

The authors investigated the hypothesis that exposure to pesticides could be related to central nervous system disorders in a prospective cohort study of 1,507 French elderly (1992-1998). Lower cognitive performance was observed in subjects who had been occupationally exposed to pesticides. In men, the relative risks of developing Parkinson's disease and Alzheimer's disease for occupational exposure assessed by a job exposure matrix were 5.63 (95% confidence interval: 1.47, 21.58) and 2.39 (95% confidence interval: 1.02, 5.63), respectively, after confounding factors were taken into account. No association was found with having a primary job in agriculture or with environmental pesticide exposure, nor was an association found in women. These results suggest the presence of neurologic impairments in elderly persons who were exposed occupationally to pesticides.

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