Dose Response of Laboratory Markers to Alcohol Consumption in a General Population | Zendy

P Sillanaukee | Zendy

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Dose Response of Laboratory Markers to Alcohol Consumption in a General Population

Author(s) -

P Sillanaukee

Publication year - 2000

Publication title -

american journal of epidemiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.33

H-Index - 256

eISSN - 1476-6256

pISSN - 0002-9262

DOI - 10.1093/aje/152.8.747

Subject(s) - carbohydrate deficient transferrin , body mass index , gamma glutamyltransferase , alcohol consumption , alcohol , medicine , population , chemistry , biochemistry , environmental health , enzyme

The dose response to alcohol use of carbohydrate-deficient transferrin (CDT), gamma-glutamyltransferase (GGT), and their combination (gamma-CDT) was studied in an age- and gender-stratified, random sample from Finland in 1997. A linear association with a threshold between alcohol consumption and the three markers was observed. Body mass index was negatively associated with CDT and positively with GGT Age was positively associated with GGT and gamma-CDT In conclusion, CDT appears to be an early phase marker of alcohol consumption. The combined marker, gamma-CDT, was less associated with factors such as body mass index but more strongly correlated with alcohol consumption than were the two markers separately.

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