Open AccessCarbohydrate and fat intake associated with risk of metabolic diseases through epigenetics of CPT1A
Author(s) -
ChaoQiang Lai,
Laurence D. Parnell,
Caren E. Smith,
Tao Guo,
Sergi Sayols-Baixeras,
Stella Aslibekyan,
Hemant K. Tiwari,
Marguerite R. Irvin,
Carl Bender,
David Fei,
Bertha Hidalgo,
Paul N. Hopkins,
Devin Absher,
Michael A. Province,
Roberto Elosúa,
Donna K. Arnett,
José M. Ordovás
Publication year - 2020
Publication title -
american journal of clinical nutrition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.608
H-Index - 336
eISSN - 1938-3207
pISSN - 0002-9165
DOI - 10.1093/ajcn/nqaa233
Subject(s) - endocrinology , medicine , carnitine , hypertriglyceridemia , dna methylation , metabolic syndrome , biology , triglyceride , epigenetics , framingham heart study , obesity , cholesterol , framingham risk score , disease , gene expression , genetics , gene
Epigenome-wide association studies identified the cg00574958 DNA methylation site at the carnitine palmitoyltransferase-1A (CPT1A) gene to be associated with reduced risk of metabolic diseases (hypertriglyceridemia, obesity, type 2 diabetes, hypertension, metabolic syndrome), but the mechanism underlying these associations is unknown.
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