Open AccessQuantitative mass spectrometry as a tool for nutritional proteomics
Author(s) -
James J. Moresco,
Meng-Qiu Dong,
John R. Yates
Publication year - 2008
Publication title -
american journal of clinical nutrition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.608
H-Index - 336
eISSN - 1938-3207
pISSN - 0002-9165
DOI - 10.1093/ajcn/88.3.597
Subject(s) - proteomics , proteome , mass spectrometry , computational biology , quantitative proteomics , chemistry , posttranslational modification , bioinformatics , biochemistry , biology , chromatography , enzyme , gene
The goal of nutritional science is to determine the effect of dietary components. Proteomics has emerged as a method to study proteins on a large scale. The proteomic information gathered from a sample, whether a biological fluid, cell, or tissue, includes not only the identities of proteins present but also their quantities and posttranslational modifications. Recent advances in mass spectrometry make it possible to accurately measure concentrations of thousands of proteins derived from such complex biological samples. Quantitative data will provide increased understanding of the dynamic changes in the proteome induced by dietary components.
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