Open AccessEffect of the melanocortin-3 receptor C17A and G241A variants on weight loss in childhood obesity
Author(s) -
Nicola Santoro,
Laura Perrone,
Grazia Cirillo,
Paolo Raimondo,
Alessandra Amato,
Carmine Brienza,
Emanuele Miraglia del Giudice
Publication year - 2007
Publication title -
american journal of clinical nutrition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.608
H-Index - 336
eISSN - 1938-3207
pISSN - 0002-9165
DOI - 10.1093/ajcn/85.4.950
Subject(s) - obesity , weight loss , medicine , body mass index , endocrinology , melanocortin 4 receptor , childhood obesity , melanocortin , receptor , overweight
The central melanocortin system is critical for the long-term regulation of energy homeostasis. Melanocortin-3 receptor (MC3R) knock-out mice, despite being hypophagic, have increased fat mass and higher feed efficiency than do their wild-type littermates.
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