Choline-related supplements improve abnormal plasma methionine-homocysteine metabolites and glutathione status in children with cystic fibrosis | Zendy

Sheila M. Innis | Zendy; A. George F. Davidson | Zendy; Stepan Melynk | Zendy; S. Jill James | Zendy

Open Access

Choline-related supplements improve abnormal plasma methionine-homocysteine metabolites and glutathione status in children with cystic fibrosis

Author(s) -

Sheila M. Innis,

A. George F. Davidson,

Stepan Melynk,

S. Jill James

Publication year - 2007

Publication title -

american journal of clinical nutrition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.608

H-Index - 336

eISSN - 1938-3207

pISSN - 0002-9165

DOI - 10.1093/ajcn/85.3.702

Subject(s) - choline , homocysteine , methionine , glutathione , betaine , glutathione disulfide , chemistry , endocrinology , medicine , phosphatidylcholine , lecithin , phosphatidylethanolamine , phospholipid , biochemistry , biology , amino acid , membrane , enzyme

Liver triacylglycerol accumulation and oxidative stress are common in cystic fibrosis (CF) and also occur in choline deficiency. Previously, we showed an association between elevated plasma homocysteine, reduced ratios of S-adenosylmethionine to S-adenosylhomocysteine (SAM:SAH) and of phosphatidylcholine to phosphatidylethanolamine, and phospholipid malabsorption in children with CF.

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