Open AccessVitamin K status of healthy Japanese women: age-related vitamin K requirement for γ-carboxylation of osteocalcin
Author(s) -
Naoko Tsugawa,
Masataka Shiraki,
Yoshitomo Suhara,
Maya Kamao,
Kiyoshi Tanaka,
Toshio Okano
Publication year - 2006
Publication title -
american journal of clinical nutrition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.608
H-Index - 336
eISSN - 1938-3207
pISSN - 0002-9165
DOI - 10.1093/ajcn/83.2.380
Subject(s) - osteocalcin , endocrinology , medicine , bone remodeling , n terminal telopeptide , chemistry , bone mineral , vitamin d and neurology , osteoporosis , creatinine , alkaline phosphatase , biochemistry , enzyme
Vitamin K deficiency is associated with low bone mineral density and increased risk of bone fracture. Phylloquinone (K1) and menaquinone 4 (MK-4) and 7 (MK-7) are generally observed in human plasma; however, data are limited on their circulating concentrations and their associations with bone metabolism or with gamma-carboxylation of the osteocalcin molecule.
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom