Open AccessPegylated human recombinant leptin (PEG-OB) causes additional weight loss in severely energy-restricted, overweight men
Author(s) -
Chris Hukshorn,
Margriet S. WesterterpPlantenga,
Wim H. M. Saris
Publication year - 2003
Publication title -
american journal of clinical nutrition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.608
H-Index - 336
eISSN - 1938-3207
pISSN - 0002-9165
DOI - 10.1093/ajcn/77.4.771
Subject(s) - leptin , appetite , overweight , medicine , endocrinology , weight loss , placebo , peg ratio , body mass index , obesity , alternative medicine , finance , pathology , economics
Increasing evidence suggests that falling leptin concentrations observed during fasting act as a peripheral signal of starvation, which serves to conserve energy in the face of limited reserves. An extension of this hypothesis is that exogenous leptin should affect energy regulation during severe energy restriction.
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