Comparison of the effect of low-dose supplementation with l-5-methyltetrahydrofolate or folic acid on plasma homocysteine: a randomized placebo-controlled study | Zendy

Bernard J. Venn | Zendy; Tim Green | Zendy; Rudolf Moser | Zendy; Jim Mann | Zendy

Open Access

Comparison of the effect of low-dose supplementation with l-5-methyltetrahydrofolate or folic acid on plasma homocysteine: a randomized placebo-controlled study

Author(s) -

Bernard J. Venn,

Tim Green,

Rudolf Moser,

Jim Mann

Publication year - 2003

Publication title -

american journal of clinical nutrition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.608

H-Index - 336

eISSN - 1938-3207

pISSN - 0002-9165

DOI - 10.1093/ajcn/77.3.658

Subject(s) - homocysteine , placebo , folic acid , fortification , medicine , vitamin , population , fortified food , food fortification , endocrinology , chemistry , food science , alternative medicine , environmental health , pathology

Food fortification with folic acid has been introduced in several countries for the prevention of neural tube defects. Fortification has lowered total homocysteine (tHcy) concentrations in the US population, a consequence that may have health benefits. However, folic acid fortification could mask vitamin B-12 deficiency. Synthetic L-5-methyltetrahydrofolate (L-MTHF) may be more appropriate than folic acid as a fortificant because it is unlikely to mask the hematologic indicators of vitamin B-12 deficiency.

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