Evidence for lack of absorption of soy isoflavone glycosides in humans, supporting the crucial role of intestinal metabolism for bioavailability | Zendy

Kenneth D.R. Setchell | Zendy; Nadine M. Brown | Zendy; Linda Zimmer-Nechemias | Zendy; Wayne T. Brashear | Zendy; Brian Wolfe | Zendy; Abby S. Kirschner | Zendy; James E. Heubi | Zendy

Open Access

Evidence for lack of absorption of soy isoflavone glycosides in humans, supporting the crucial role of intestinal metabolism for bioavailability

Author(s) -

Kenneth D.R. Setchell,

Nadine M. Brown,

Linda Zimmer-Nechemias,

Wayne T. Brashear,

Brian Wolfe,

Abby S. Kirschner,

James E. Heubi

Publication year - 2002

Publication title -

american journal of clinical nutrition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.608

H-Index - 336

eISSN - 1938-3207

pISSN - 0002-9165

DOI - 10.1093/ajcn/76.2.447

Subject(s) - genistin , daidzin , bioavailability , chemistry , isoflavones , daidzein , glycoside , genistein , chromatography , biochemistry , pharmacology , endocrinology , medicine , stereochemistry

The isoflavones daidzein and genistein occur naturally in most soyfoods, conjugated almost exclusively to sugars. Controversy exists regarding the extent of bioavailability of isoflavone glycosides, and the mechanism of intestinal absorption of isoflavones in humans is unclear. Evidence from intestinal perfusion and in vitro cell culture studies indicates that isoflavone glycosides are poorly absorbed, yet isoflavones are bioavailable and appear in high concentrations in plasma, irrespective of whether they are ingested as aglycones or glycoside conjugates.

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