Impaired functioning of thermolabile methylenetetrahydrofolate reductase is dependent on riboflavin status: implications for riboflavin requirements | Zendy

Helene McNulty | Zendy; Michelle C. McKinley | Zendy; Barbara J. Wilson | Zendy; Joseph McPartlin | Zendy; JJ Strain | Zendy; Donald G. Weir | Zendy; John M. Scott | Zendy

Open Access

Impaired functioning of thermolabile methylenetetrahydrofolate reductase is dependent on riboflavin status: implications for riboflavin requirements

Author(s) -

Helene McNulty,

Michelle C. McKinley,

Barbara J. Wilson,

Joseph McPartlin,

JJ Strain,

Donald G. Weir,

John M. Scott

Publication year - 2002

Publication title -

american journal of clinical nutrition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.608

H-Index - 336

eISSN - 1938-3207

pISSN - 0002-9165

DOI - 10.1093/ajcn/76.2.436

Subject(s) - methylenetetrahydrofolate reductase , thermolabile , riboflavin , homocysteine , reductase , medicine , b vitamins , genotype , flavin adenine dinucleotide , vitamin , chemistry , endocrinology , biochemistry , cofactor , biology , enzyme , gene

Methylenetetrahydrofolate reductase (MTHFR; EC 1.7.99.5) supplies the folate needed for the metabolism of homocysteine. A reduction in MTHFR activity, as occurs in the homozygous state for the 677C-->T (so-called thermolabile) enzyme variant (TT genotype), is associated with an increase in plasma total homocysteine (tHcy).

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