Open AccessGenomic DNA methylation decreases in response to moderate folate depletion in elderly women
Author(s) -
Gail C. Rampersaud,
Gail Kauwell,
Alan D. Hutson,
James J. Cerda,
Lynn B. Bailey
Publication year - 2000
Publication title -
american journal of clinical nutrition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.608
H-Index - 336
eISSN - 1938-3207
pISSN - 0002-9165
DOI - 10.1093/ajcn/72.4.998
Subject(s) - dna methylation , methylation , dna , genetics , genome instability , genomic dna , biology , medicine , chemistry , gene , dna damage , gene expression
Methylation of genomic DNA is dependent on an adequate supply of folate coenzymes. Previous data support the hypothesis that abnormal DNA methylation plays an integral role in carcinogenesis. To date, no studies assessing the effect of inadequate folate status on DNA methylation in older women (aged >63 y) have been reported.
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