Effects of sesamin-supplemented dietary fat emulsions on the ex vivo production of lipopolysaccharide-induced prostanoids and tumor necrosis factor α in rats | Zendy

Tohru Utsunomiya | Zendy; S.R. Chavali | Zendy; Wuning Zhong | Zendy; R. Armour Forse | Zendy

Open Access

Effects of sesamin-supplemented dietary fat emulsions on the ex vivo production of lipopolysaccharide-induced prostanoids and tumor necrosis factor α in rats

Author(s) -

Tohru Utsunomiya,

S.R. Chavali,

Wuning Zhong,

R. Armour Forse

Publication year - 2000

Publication title -

american journal of clinical nutrition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.608

H-Index - 336

eISSN - 1938-3207

pISSN - 0002-9165

DOI - 10.1093/ajcn/72.3.804

Subject(s) - sesamin , prostaglandin e2 , alpha linolenic acid , linseed oil , prostaglandin , chemistry , endocrinology , arachidonic acid , medicine , tumor necrosis factor alpha , eicosanoid , lipopolysaccharide , linoleic acid , biochemistry , fatty acid , biology , food science , polyunsaturated fatty acid , docosahexaenoic acid , enzyme

Sesamin, a nonfat constituent of sesame oil, inhibits Delta(5)-desaturase activity, resulting in accumulation of dihomo-gamma-linolenic acid (DGLA), which displaces arachidonic acid (AA) and consequently decreases the formation of proinflammatory 2-series prostaglandins.

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