Open AccessTaurine improves insulin sensitivity in the Otsuka Long-Evans Tokushima Fatty rat, a model of spontaneous type 2 diabetes
Author(s) -
Yutaka Nakaya,
Asako Minami,
Nagakatsu Harada,
S. Sakamoto,
Yasuharu Niwa,
Masaharu OHNAKA
Publication year - 2000
Publication title -
american journal of clinical nutrition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.608
H-Index - 336
eISSN - 1938-3207
pISSN - 0002-9165
DOI - 10.1093/ajcn/71.1.54
Subject(s) - medicine , taurine , endocrinology , insulin resistance , diabetes mellitus , type 2 diabetes , insulin , excretion , streptozotocin , chemistry , biochemistry , amino acid
Taurine, a potent antioxidant, has been reported to improve streptozotocin-induced diabetes mellitus, in which the development of diabetes results from an attack by oxygen free radicals on pancreatic beta cells. However, taurine also increases the excretion of cholesterol via conversion to bile acid and would be expected to improve insulin resistance.
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