Choline deficiency in mice and humans is associated with increased plasma homocysteine concentration after a methionine load | Zendy

Kerry-Ann da Costa | Zendy; Christopher E. Gaffney | Zendy; Leslie M. Fischer | Zendy; Steven H. Zeisel | Zendy

Open Access

Choline deficiency in mice and humans is associated with increased plasma homocysteine concentration after a methionine load

Author(s) -

Kerry-Ann da Costa,

Christopher E. Gaffney,

Leslie M. Fischer,

Steven H. Zeisel

Publication year - 2005

Publication title -

american journal of clinical nutrition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.608

H-Index - 336

eISSN - 1938-3207

pISSN - 0002-9165

DOI - 10.1093/ajcn.81.2.440

Subject(s) - choline , homocysteine , methionine , endocrinology , betaine , medicine , methylation , chemistry , biology , biochemistry , amino acid , gene

Elevated concentrations of homocysteine in blood may be an independent risk factor for the development of atherosclerosis. Elevated homocysteine concentrations can be caused by decreased methylation of homocysteine to form methionine, as occurs in folate deficiency. A parallel pathway exists for methylation of homocysteine, in which choline, by way of betaine, is the methyl donor.

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