Pisa syndrome due to donepezil: pharmacokinetic interactions to blame? | Zendy

David Pollock | Zendy; Emma Cunningham | Zendy; Bernadette McGuinness | Zendy; Anthony Peter Passmore | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Pisa syndrome due to donepezil: pharmacokinetic interactions to blame?

Author(s) -

David Pollock,

Emma Cunningham,

Bernadette McGuinness,

Anthony Peter Passmore

Publication year - 2016

Publication title -

age and ageing

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.014

H-Index - 143

eISSN - 1468-2834

pISSN - 0002-0729

DOI - 10.1093/ageing/afw253

Subject(s) - donepezil , medicine , acetylcholinesterase inhibitor , pharmacokinetics , acetylcholinesterase , intensive care medicine , dementia , pharmacology , disease , biochemistry , chemistry , enzyme

We report a case of Pisa syndrome (PS) due to the acetylcholinesterase inhibitor donepezil which may have been precipitated by pharmacokinetic interactions with commonly used medications. PS is defined as a reversible lateral bending of the trunk with a tendency to lean to one side. This is a rare but very distressing complication with this commonly used medication which was not initially recognised, leading to increasing disability for the patient and significant carer stress. Cessation of donepezil and modulation of potential interacting medications resulted in complete resolution.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research