Alzheimer disease genetic risk factorAPOEe4 and cognitive abilities in 111,739 UK Biobank participants | Zendy

Donald M. Lyall | Zendy; Joey Ward | Zendy; Stuart J. Ritchie | Zendy; Gail Davies | Zendy; Breda Cullen | Zendy; Carlos LópezdeCelis | Zendy; Mark E.S. Bailey | Zendy; Jana Anderson | Zendy; Jonathan J. Evans | Zendy; D McKay | Zendy; Andrew M. McIntosh | Zendy; Naveed Sattar | Zendy; Daniel J. Smıth | Zendy; Ian J. Deary | Zendy; Jill P. Pell | Zendy

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Alzheimer disease genetic risk factorAPOEe4 and cognitive abilities in 111,739 UK Biobank participants

Author(s) -

Donald M. Lyall,

Joey Ward,

Stuart J. Ritchie,

Gail Davies,

Breda Cullen,

Carlos LópezdeCelis,

Mark E.S. Bailey,

Jana Anderson,

Jonathan J. Evans,

D McKay,

Andrew M. McIntosh,

Naveed Sattar,

Daniel J. Smıth,

Ian J. Deary,

Jill P. Pell

Publication year - 2016

Publication title -

age and ageing

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.014

H-Index - 143

eISSN - 1468-2834

pISSN - 0002-0729

DOI - 10.1093/ageing/afw068

Subject(s) - dementia , apolipoprotein e , medicine , cognitive decline , biobank , confounding , cognition , disease , mendelian randomization , risk factor , gerontology , alzheimer's disease , effects of sleep deprivation on cognitive performance , psychiatry , bioinformatics , genetics , genotype , biology , genetic variants , gene

he apolipoprotein (APOE) e4 locus is a genetic risk factor for dementia. Carriers of the e4 allele may be more vulnerable to conditions that are independent risk factors for cognitive decline, such as cardiometabolic diseases.

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