Genetic variant ofInterleukin-18gene is associated with the Frailty Index in the English Longitudinal Study of Ageing | Zendy

Krisztina Mekli | Zendy; Alan Marshall | Zendy; James Nazroo | Zendy; Bram Vanhoutte | Zendy; Neil Pendleton | Zendy

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Genetic variant ofInterleukin-18gene is associated with the Frailty Index in the English Longitudinal Study of Ageing

Author(s) -

Krisztina Mekli,

Alan Marshall,

James Nazroo,

Bram Vanhoutte,

Neil Pendleton

Publication year - 2015

Publication title -

age and ageing

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.014

H-Index - 143

eISSN - 1468-2834

pISSN - 0002-0729

DOI - 10.1093/ageing/afv122

Subject(s) - medicine , ageing , longitudinal study , frailty index , gerontology , bonferroni correction , bioinformatics , pathology , biology , statistics , mathematics

The term frailty refers to a condition of increased vulnerability to stressors among older people, leading to a decline in homeostatic reserve. Frailty often leads to falls, hospitalisation and mortality, hence its importance for the delivery of health care to older adults. The pathophysiological mechanisms behind frailty are not well understood, but the decreased steroid-hormone production and elevated chronic systemic inflammation of older people appear to be major contributors.

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