Abnormal levels of brain metabolites may mediate cognitive impairment in stroke-free patients with cerebrovascular risk factors | Zendy

Dong Sun | Zendy; J. Zhang | Zendy; Fan Yang | Zendy; Xuan Liu | Zendy; Y. Gao | Zendy; Guangyao Wu | Zendy; Yu Yan | Zendy; Junjie Zeng | Zendy

Open Access

Abnormal levels of brain metabolites may mediate cognitive impairment in stroke-free patients with cerebrovascular risk factors

Author(s) -

Dong Sun,

J. Zhang,

Fan Yang,

Xuan Liu,

Y. Gao,

Guangyao Wu,

Yu Yan,

Junjie Zeng

Publication year - 2014

Publication title -

age and ageing

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.014

H-Index - 143

eISSN - 1468-2834

pISSN - 0002-0729

DOI - 10.1093/ageing/afu027

Subject(s) - medicine , glutamine , creatine , stroke (engine) , prefrontal cortex , hippocampal formation , glutamate receptor , hippocampus , cardiology , cognition , endocrinology , psychiatry , biochemistry , biology , mechanical engineering , receptor , amino acid , engineering

conventional vascular risk factors (VRFs) are associated with cognitive impairment independent of stroke and detectable cerebral lesions. We used proton magnetic resonance spectroscopy ((1)H MRS) to examine the hypotheses that abnormal levels of brain metabolites may mediate the relationship between VRFs and cognitive impairment.

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