C-reactive protein, APOE genotype and longitudinal cognitive change in an older population | Zendy

T. A. S. Lima | Zendy; Amanda L. Adler | Zendy; Thaı́s Minett | Zendy; Fiona E. Matthews | Zendy; Carol Brayne | Zendy; Riccardo E. Marioni | Zendy

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C-reactive protein, APOE genotype and longitudinal cognitive change in an older population

Author(s) -

T. A. S. Lima,

Amanda L. Adler,

Thaı́s Minett,

Fiona E. Matthews,

Carol Brayne,

Riccardo E. Marioni

Publication year - 2013

Publication title -

age and ageing

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.014

H-Index - 143

eISSN - 1468-2834

pISSN - 0002-0729

DOI - 10.1093/ageing/aft193

Subject(s) - medicine , apolipoprotein e , confounding , cognitive decline , c reactive protein , odds ratio , longitudinal study , population , allele , cognition , demography , gerontology , dementia , inflammation , psychiatry , pathology , genetics , biology , disease , environmental health , sociology , gene

circulating measures of inflammatory markers, such as C-reactive protein (CRP) have been associated with an increased risk of future cognitive decline. However, the nature of the relationship among the very old (>75 years) is unclear. Cross-sectional evidence suggests that elevated CRP may even be protective in this age group. This study examines these associations longitudinally.

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