Low preoperative plasma cholinesterase activity as a risk marker of postoperative delirium in elderly patients | Zendy

Joaquim Cerejeira | Zendy; Pedro Batista | Zendy; V. Nogueira | Zendy; Horácio Firmino | Zendy; Adriano VazSerra | Zendy; Elizabeta B. MukaetovaLadinska | Zendy

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Low preoperative plasma cholinesterase activity as a risk marker of postoperative delirium in elderly patients

Author(s) -

Joaquim Cerejeira,

Pedro Batista,

V. Nogueira,

Horácio Firmino,

Adriano VazSerra,

Elizabeta B. MukaetovaLadinska

Publication year - 2011

Publication title -

age and ageing

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.014

H-Index - 143

eISSN - 1468-2834

pISSN - 0002-0729

DOI - 10.1093/ageing/afr053

Subject(s) - delirium , medicine , butyrylcholinesterase , acetylcholinesterase , cholinesterase , pathophysiology , rivastigmine , cohort , cholinergic , anesthesia , aché , intensive care medicine , dementia , disease , donepezil , enzyme , biochemistry , chemistry

delirium is a frequent neuropsychiatric syndrome affecting medical and surgical elderly patients. Cholinergic dysfunction has been implicated in delirium pathophysiology and plasmatic acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) activities are suppressed in patients with delirium. In this cohort study, we investigated whether these changes emerge during delirium or whether they are present before its onset.

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