IL-6-independent association of elevated serum neopterin levels with prevalent frailty in community-dwelling older adults | Zendy

S. X. Leng | Zendy; Xinlun Tian | Zendy; Amy M. Matteini | Zendy; Huai Li | Zendy; John A. Hughes | Zendy; Amit Jain | Zendy; Jeremy Walston | Zendy; Neal S. Fedarko | Zendy

Open Access

IL-6-independent association of elevated serum neopterin levels with prevalent frailty in community-dwelling older adults

Author(s) -

S. X. Leng,

Xinlun Tian,

Amy M. Matteini,

Huai Li,

John A. Hughes,

Amit Jain,

Jeremy Walston,

Neal S. Fedarko

Publication year - 2011

Publication title -

age and ageing

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.014

H-Index - 143

eISSN - 1468-2834

pISSN - 0002-0729

DOI - 10.1093/ageing/afr047

Subject(s) - neopterin , medicine , confidence interval , odds ratio , body mass index , gerontology

neopterin is a monocyte/macrophage-derived immune activation marker and its levels increase with age. Frailty is an important clinical syndrome of old age. Previous studies have shown significant association between elevated interleukin-6 (IL-6) levels and frailty. The objective of this study was to evaluate IL-6-independent association of serum neopterin levels with prevalent frailty.

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