A preliminary study of the safety, feasibility and cognitive efficacy of soy isoflavone supplements in older men and women | Zendy

Carey E. Gleason | Zendy; Cynthia M. Carlsson | Zendy; Jodi H. Barnet | Zendy; S. A. Meade | Zendy; Kenneth D.R. Setchell | Zendy; Craig Atwood | Zendy; Sterling C. Johnson | Zendy; Michele L. Ries | Zendy; S. Asthana | Zendy

Open Access

A preliminary study of the safety, feasibility and cognitive efficacy of soy isoflavone supplements in older men and women

Author(s) -

Carey E. Gleason,

Cynthia M. Carlsson,

Jodi H. Barnet,

S. A. Meade,

Kenneth D.R. Setchell,

Craig Atwood,

Sterling C. Johnson,

Michele L. Ries,

S. Asthana

Publication year - 2008

Publication title -

age and ageing

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.014

H-Index - 143

eISSN - 1468-2834

pISSN - 0002-0729

DOI - 10.1093/ageing/afn227

Subject(s) - daidzein , genistein , isoflavones , placebo , medicine , equol , verbal fluency test , cognition , phytoestrogens , clinical trial , endocrinology , physiology , psychiatry , alternative medicine , estrogen , pathology , neuropsychology

a small number of reports exist on the cognitive effects of soy isoflavones, the findings from which are mixed. Isoflavone efficacy is dependent upon conversion of glycosides contained in soy foods and supplements to the biologically active aglycons. Of particular interest is the production of the metabolite, equol, which is dependent upon intestinal microflora and an integrous digestive system, both being altered by age and age-associated conditions. Unfortunately, few studies enrolled adults over the age of 70, and none included older men.

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