Age-related increases in DNA repair and antioxidant protection: A comparison of the Boyd Orr Cohort of elderly subjects with a younger population sample | Zendy

Vikki Humphreys | Zendy; Richard M. Martin | Zendy; B. Ratcliffe | Zendy; Susan J. Duthie | Zendy; S. Wood | Zendy; D. Gunnell | Zendy; Andrew Collins | Zendy

Open Access

Age-related increases in DNA repair and antioxidant protection: A comparison of the Boyd Orr Cohort of elderly subjects with a younger population sample

Author(s) -

Vikki Humphreys,

Richard M. Martin,

B. Ratcliffe,

Susan J. Duthie,

S. Wood,

D. Gunnell,

Andrew Collins

Publication year - 2007

Publication title -

age and ageing

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.014

H-Index - 143

eISSN - 1468-2834

pISSN - 0002-0729

DOI - 10.1093/ageing/afm107

Subject(s) - antioxidant , dna damage , ageing , dna repair , comet assay , population , reactive oxygen species , oxidative phosphorylation , dna , medicine , oxidative stress , biochemistry , immunology , biology , environmental health

One commonly held theory of ageing is that it is caused by oxidative damage to critical molecules in the body, including proteins, lipids and nucleic acids. Accumulation of oxidative DNA damage with age will occur if there is an increase in reactive oxygen species in the body, or a decline in antioxidant defences, or a reduced efficiency of DNA repair.

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