Open AccessThe presence of leuko-araiosis in patients with Alzheimer's disease predicts poor tolerance to tacrine, but does not discriminate responders from non-responders
Author(s) -
Khaled Amar,
Gordon Wilcock,
Margaret Scot,
Tim Lewis
Publication year - 1997
Publication title -
age and ageing
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.014
H-Index - 143
eISSN - 1468-2834
pISSN - 0002-0729
DOI - 10.1093/ageing/26.1.25
Subject(s) - tacrine , medicine , anesthesia , alzheimer's disease , disease , biochemistry , chemistry , acetylcholinesterase , enzyme
approximately one-third of patients with Alzheimer's disease (AD) respond favourably to the anticholinesterase tacrine, but the drug's usefulness is marred by a high incidence of side-effects.